Tutorial on LTE/LTE-A Cellular Network Dimensioning Using Iterative Statistical Analysis

LTE is the fastest growing cellular technology and is expected to increase its footprint in the coming years, as well as progress toward LTE-A. The race among operators to deliver the expected quality of experience to their users is tight and demands sophisticated skills in network planning. Radio network dimensioning (RND) is an essential step in the process of network planning and has been used as a fast, but indicative, approximation of radio site count. RND is a prerequisite to the lengthy process of thorough planning. Moreover, results from RND are used by players in the industry to estimate preplanning costs of deploying and running a network; thus, RND is, as well, a key tool in cellular business modelling. In this work, we present a tutorial on radio network dimensioning, focused on LTE/LTE-A, using an iterative approach to find a balanced design that mediates among the three design requirements: coverage, capacity, and quality. This approach uses a statistical link budget analysis methodology, which jointly accounts for small and large scale fading in the channel, as well as loading due to traffic demand, in the interference calculation. A complete RND manual is thus presented, which is of key importance to operators deploying or upgrading LTE/LTE-A networks for two reasons. It is purely analytical, hence it enables fast results, a prime factor in the race undertaken. Moreover, it captures essential variables affecting network dimensions and manages conflicting targets to ensure user quality of experience, another major criterion in the competition. The described approach is compared to the traditional RND using a commercial LTE network planning tool. The outcome further dismisses the traditional RND for LTE due to unjustified increase in number of radio sites and related cost, and motivates further research in developing more effective and novel RND procedures

Planning Wireless Cellular Networks of Future: Outlook, Challenges and Opportunities

Cell planning (CP) is the most important phase in the life cycle of a cellular system as it determines the operational expenditure, capital expenditure, as well as the long-term performance of the system. Therefore, it is not surprising that CP problems have been studied extensively for the past three decades for all four generations of cellular systems. However, the fact that small cells, a major component of future networks, are anticipated to be deployed in an impromptu fashion makes CP for future networks vis-a-vis 5G a conundrum. Furthermore, in emerging cellular systems that incorporate a variety of different cell sizes and types, heterogeneous networks (HetNets), energy efficiency, self-organizing network features, control and data plane split architectures (CDSA), massive multiple input multiple out (MIMO), coordinated multipoint (CoMP), cloud radio access network, and millimetre-wave-based cells plus the need to support Internet of Things (IoT) and device-to-device (D2D) communication require a major paradigm shift in the way cellular networks have been planned in the past. The objective of this paper is to characterize this paradigm shift by concisely reviewing past developments, analyzing the state-of-the-art challenges, and identifying future trends, challenges, and opportunities in CP in the wake of 5G. More specifically, in this paper, we investigate the problem of planning future cellular networks in detail. To this end, we first provide a brief tutorial on the CP process to identify the peculiarities that make CP one of the most challenging problems in wireless communications. This tutorial is followed by a concise recap of past research in CP. We then review key findings from recent studies that have attempted to address the aforementioned challenges in planning emerging networks. Finally, we discuss the range of technical factors that need to be taken into account while planning future networks and the promising research directions that necessitates the paradigm shift to do so

An eHealth-Care Driven Perspective on 5G Networks and Infrastructure

This work describes the advancements that next generation mobile networks can bring to emergency services on the basis of a fully 5G enabled medical emergency response scenario. An ambulance service combining autonomous driving, advanced on-board patient monitoring, remote diagnosis and remote control from the hospital is introduced, allowing increased levels of care during patient transport and improved early diagnosis, thus enhancing patient survival rates. Furthermore, it is shown that such an ambulance service requires a variety of different traffic types that can only be supported concurrently and with guaranteed quality of service by a high-performance network fulfilling all 5G key performance indicators. The scenario described combines a multitude of aspects and applications enabled by 5G mobile communications, including autonomous driving, ultra-high definition video streaming, tactile remote interaction and continuous sensing, into a compelling showcase for a 5G enabled future. A centralized radio access 5G network with space division multiplexed optical fronthaul using analog radio-over-fiber and optical beamforming is analyzed, fully supporting SDN and NFV for advanced network slicing and quality of service guarantee.</p

An entropy test for single-locus genetic association analysis

<p>Abstract</p> <p>Background</p> <p>The etiology of complex diseases is due to the combination of genetic and environmental factors, usually many of them, and each with a small effect. The identification of these small-effect contributing factors is still a demanding task. Clearly, there is a need for more powerful tests of genetic association, and especially for the identification of rare effects</p> <p>Results</p> <p>We introduce a new genetic association test based on symbolic dynamics and symbolic entropy. Using a freely available software, we have applied this entropy test, and a conventional test, to simulated and real datasets, to illustrate the method and estimate type I error and power. We have also compared this new entropy test to the Fisher exact test for assessment of association with low-frequency SNPs. The entropy test is generally more powerful than the conventional test, and can be significantly more powerful when the genotypic test is applied to low allele-frequency markers. We have also shown that both the Fisher and Entropy methods are optimal to test for association with low-frequency SNPs (MAF around 1-5%), and both are conservative for very rare SNPs (MAF<1%)</p> <p>Conclusions</p> <p>We have developed a new, simple, consistent and powerful test to detect genetic association of biallelic/SNP markers in case-control data, by using symbolic dynamics and symbolic entropy as a measure of gene dependence. We also provide a standard asymptotic distribution of this test statistic. Given that the test is based on entropy measures, it avoids smoothed nonparametric estimation. The entropy test is generally as good or even more powerful than the conventional and Fisher tests. Furthermore, the entropy test is more computationally efficient than the Fisher's Exact test, especially for large number of markers. Therefore, this entropy-based test has the advantage of being optimal for most SNPs, regardless of their allele frequency (Minor Allele Frequency (MAF) between 1-50%). This property is quite beneficial, since many researchers tend to discard low allele-frequency SNPs from their analysis. Now they can apply the same statistical test of association to all SNPs in a single analysis., which can be especially helpful to detect rare effects.</p

Identification of human-to-human transmissibility factors in PB2 proteins of influenza A by large-scale mutual information analysis

<p>Abstract</p> <p>Background</p> <p>The identification of mutations that confer unique properties to a pathogen, such as host range, is of fundamental importance in the fight against disease. This paper describes a novel method for identifying amino acid sites that distinguish specific sets of protein sequences, by comparative analysis of matched alignments. The use of mutual information to identify distinctive residues responsible for functional variants makes this approach highly suitable for analyzing large sets of sequences. To support mutual information analysis, we developed the AVANA software, which utilizes sequence annotations to select sets for comparison, according to user-specified criteria. The method presented was applied to an analysis of influenza A PB2 protein sequences, with the objective of identifying the components of adaptation to human-to-human transmission, and reconstructing the mutation history of these components.</p> <p>Results</p> <p>We compared over 3,000 PB2 protein sequences of human-transmissible and avian isolates, to produce a catalogue of sites involved in adaptation to human-to-human transmission. This analysis identified 17 characteristic sites, five of which have been present in human-transmissible strains since the 1918 Spanish flu pandemic. Sixteen of these sites are located in functional domains, suggesting they may play functional roles in host-range specificity. The catalogue of characteristic sites was used to derive sequence signatures from historical isolates. These signatures, arranged in chronological order, reveal an evolutionary timeline for the adaptation of the PB2 protein to human hosts.</p> <p>Conclusion</p> <p>By providing the most complete elucidation to date of the functional components participating in PB2 protein adaptation to humans, this study demonstrates that mutual information is a powerful tool for comparative characterization of sequence sets. In addition to confirming previously reported findings, several novel characteristic sites within PB2 are reported. Sequence signatures generated using the characteristic sites catalogue characterize concisely the adaptation characteristics of individual isolates. Evolutionary timelines derived from signatures of early human influenza isolates suggest that characteristic variants emerged rapidly, and remained remarkably stable through subsequent pandemics. In addition, the signatures of human-infecting H5N1 isolates suggest that this avian subtype has low pandemic potential at present, although it presents more human adaptation components than most avian subtypes.</p

Measurement-Based Signaling Management Strategies for Cellular IoT

In the future, all devices that benefit from an Internet connection will be connected. Internet of Things technologies are key enablers of this vision by moving beyond basic connectivity machine-to-machine (M2M) communications brings to more intelligent interconnection of physical things on a massive scale. This anticipated growth is expected to challenge the planning and operation of cellular networks due to new diverse traffic models and high signaling loads. In this paper, we conduct a detailed experimental study using state-of-the-art drive testing equipment in order to measure, quantify, and analyze the signaling overhead of two classes of M2M services that resemble smart metering and vehicular applications. Two practical signaling reduction techniques are proposed and analyzed, with focus on aggregation as an efficient approach to overcome the resulting surge in signaling load. We complement the experimental results with an analytical evaluation to quantify the tradeoffs between M2M data transmission delay and the level of aggregation. Moreover, we present a novel case study to assess the potential negative impact of M2M signaling traffic on network planning and operation in 4G cellular networks